Oral food and drug challenge are used as an ultimate method to rule out the food or drug allergy in question. Oral challenge is not done for diagnosis purpose. It is indicated when all other tests have been done showing a low risk of developing a clinical reaction to that particular food or drug. It should be done in a supervised environment since there are still risks of having an adverse reaction or even anaphylaxis during the challenge. During the process, you would ingest a small amount of the food or drugs in questions with progressive increase of the dose over time. At the same time, your nurse and physician would continuously monitor you for any early signs of allergic reactions. You would expect to spend at least 2 hours to half a day in the allergy clinic for this procedure.